• Tear miRNA expression analysis reveals miR-203 as a potential regulator of corneal epithelial

    Ayumi Nakagawa 1, Takeshi Nakajima 2 and Mitsuyoshi Azuma 2

    1 Central Research Laboratories, Research and Development Division, Senju Pharmaceutical Co., Ltd.

    2 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd.

    BMC Ophthalmology 2021;21(1):377.

  • TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure

    Takatoshi Uchida 1 2, Shota Shimizu 1 2, Reiko Yamagishi 1, Suzumi M. Tokuoka 3, Yoshihiro Kita 3 4, Rei Sakata 1, Megumi Honjo 1, Makoto Aihara 1

    1 Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

    2 Senju Laboratory of Ocular Science, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

    3 Department of Lipidomics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

    4 Life Science Core Facility, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

    PLoS One. 2021; 16:e0258911.

  • 緑内障・高眼圧症治療剤：ブリモニジン酒石酸塩・ブリンゾラミド配合点眼液「アイラミド®配合懸濁性点眼液」

    上原 麻未、山下 敦子、重見 稚紗、玉田 義之

    眼薬理 35:24-27, 2021©

  • Meeting Report of the Technical Education Committee Symposium: Management of DNA reactive (mutagenic) impurities in drug development

    Yusuke Nagato 1, Junichi Fukuchi 2, Muneki Kishida 3, Hiroki Ueoka 4, Yosuke Mino 5, Andrew Teasdale 6, Akio Imai 7, Hideki Kumobayashi 7, Dai Sugiura 8, Makoto Yokoyama 7 and Yukio Hiyama 9

    1 FUJIFILM Corporation,

    2 Pharmaceuticals and Medical Devices Agency,

    3 Mitsubishi Tanabe Pharma Corporation,

    4 Senju Pharmaceutical Co., Ltd.,

    5 Japan Tabacco Inc.,

    6 AstraZeneca,

    7 Eisai Co., Ltd.,

    8 TERUMO Corporation,

    9 National Institute of Health Sciences

    PDA Journal of GMP and Validation in Japan Vol. 23, No. 1 (2021) 1-12.

  • Stratification-based investigation of adjunctive brimonidine or timolol to a prostaglandin analogue in Japanese patients with normal-tension glaucoma

    Keiji Yoshikawa 1, Shiro Mizoue 2,3, Koji Nitta 4, Hiroshi Onishi 5, Masaharu Ikeda 5, Akemi Mizuno 5, Kaori Kawazoe 5, Yoshiyuki Tamada 5, Ryuji Takeda 6, Shun Matsumoto 7

    1 Yoshikawa Eye Clinic, Tokyo, Japan;

    2 Ehime University Hospital, Ehime, Japan;

    3 Minami-Matsuyama Hospital, Ehime, Japan;

    4 Fukui-ken Saiseikai Hospital, Fukui, Japan;

    5 Senju Pharmaceutical Co. Ltd., Hyogo, Japan;

    6 Kansai University of Welfare Sciences, Osaka, Japan;

    7 Ideta Eye Hospital, Kumamoto, Japan

    Clinical Ophthalmology 2021;15:2875–2883

  • Orbital malignant schwannoma and embryonal rhabdomyosarcoma in rats caused by leakage of locally injected nickel subsulfide to the orbit

    Yoshinori Yamagiwa 1,2, Miki Masatsugu 1, Haruna Tahara 1, Kotaro Yamada 1, Yu Haranosono 1,Masaaki Kurata 1, and Hiroshi Satoh 2

    1 千寿製薬株式会社

    2 岩手大学大学院獣医学研究科

    J Toxicol Pathol 2021; 34: 151–156

  • 0.3% ロメフロキサシンのイヌ細菌性外耳炎に対する有効性と安全性に関する調査

    貞本和代2、坂本祐一郎2、門屋美知代1、末信敏秀2

    1 かどやアニマルホスピタル

    2 千寿製薬株式会社

    獣医臨床皮膚科27(1):11-19,2021

  • In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds

    Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono and Masaaki Kurata

    Genes and Environment. 2021, 43:11.

  • Histological Features of Postnatal Development of the Eye in White Rabbits

    山際慶典１,２、倉田昌明１、佐藤洋２

    1 千寿製薬株式会社

    2 岩手大学大学院獣医学研究科

    Toxicologic Pathology 2021;49(3):419-437

  • Mechanical stretch induces Ca2+ influx and extracellular release of ­PGE2 through Piezo1 activation in trabecular meshwork cells

    Takatoshi Uchida1,2, Shota Shimizu1,2, ReikoYamagishi1, Suzumi M.Tokuoka3,Yoshihiro Kita3,4, Megumi Honjo1 & MakotoAihara1

    1 Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7‑3‑1, Hongo, Bunkyo‑ku, Tokyo 113‑8655, Japan.

    2 Senju Laboratory of Ocular Science, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

    3 Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

    4 LifeScience Core Facility, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

    Scientific Reports. 2021;11:4044

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