Publications2014

Establishment of an in silico phototoxicity prediction method by combining descriptors related to photo-absorption and photo-reaction

  • Yu Haranosono, Masaaki Kurata and Hideyuki Sakaki
  • The Journal of Toxicogical Science 2014 vol.39 No. 4 655-664

Mechanism for laser-induced neovascularization in rat choroid: accumulation of integrin α chain-positive cells and their ligands.

  • Takeshi Nakajima 1, Masayuki Hirata 1,2, Thomas R. Shearer 1, Mitsuyoshi. Azuma 1,2
    1 Senju Pharmaceutical Co., Ltd.
    2 Oregon Health & Science University
  • Mol Vis. 2014 Jun 19;20:864-71

Degeneration and dysfunction of retinal neurons in acute ocular hypertensive rats: involvement of calpains.

  • Suzuki R 1, Oka T 1, Tamada Y 1, Shearer TR 2, Azuma M 1,2
    1 Senju Pharmaceutical Co., Ltd.
    2 Oregon Health & Science University
  • J Ocul Pharmacol Ther. 2014 Jun;30(5):419-28

Dry eye in LASIK patients

  • Azuma M1,3, Yabuta C1, Fraunfelder FW2, Shearer TR3
    1 Senju Pharmaceutical Co., Ltd.
    2 Department of Ophthalmology, Oregon Health & Science University
    3 Department of Integrative Biosciences, Oregon Health & Science University
  • BMC Res Notes. 2014 Jul 3;7:420

Pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs in retinochoroidal tissues in rabbits.

  • Tetsuo Kida1,2, Seiko Kozai1, Hiroaki Takahashi1, Mitsuyoshi Isaka1, Hideki Tokushige1, Taiji Sakamoto2
    1 Senju Pharmaceutical Co., Ltd.
    2 Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences
  • PLoS One. 2014;9(5):e96481

Loss of calpastatin leads to activation of calpain in human lens epithelial cells.

  • Nakajima T1, Shearer TR2, Azuma M1,2
    1 Senju Pharmaceutical Co., Ltd.
    2 Department of Integrative Biosciences, Oregon Health & Science University
  • Invest Ophthalmol Vis Sci. 2014 Jul 22;55(8):5278-83.

Comparative Studies of N-Glycans and Glycosaminoglycans Present in SIRC (Statens Seruminstitut Rabbit Cornea) Cells and Corneal Epithelial Cells from Rabbit Eyes

  • Kinya Iwatsuka 1, Hiroki Iwamoto 2, Mitsuhiro Kinoshita 2, Katsuhiro Inada 1, Shin-ichi Yasueda 1, Kazuaki Kakehi 2
    1 Senju Pharmaceutical CO.,LTD.
    2 Kinki University
  • Curr Eye Res.2014;39(7):686-694

Comparative study on ocular anatomical features among rabbits, beagle dogs and cynomolgus monkeys

  • Ikuyo Atsumi, Masaaki Kurata, Hideyuki Sakaki
  • Animal Eye Research. 2013;32:35-41.

Calpain Protease Causes Hypoxia-Induced Proteolysis in Cultured Human Retina.

  • Mitsuyoshi Azuma1,2, Katherine B. Hammond1, Emi Nakajima1,2, Thomas R. Shearer2
    1 Senju Pharmaceutical Co., Ltd.
    2 Oregon Health & Science University
  • Curr Eye Res.2014;39(4):421-424

Drug Penetration of the Posterior Eye Tissues after Topical Instillation: In Vivo and In Silico Simulation

  • Yuko Shikamura 1,2, Akira Ohtori 1,2, Kakuji Tojo 2
    1 Senju Pharmaceutical Co., Ltd.
    2 Kyushu Institute of Technology
  • Chem. Pharm. Bull. 59(10) 1263-1267 (2011)

Activation of the mitochondrial caspase pathway and subsequent calpain activation in monkey RPE cells cultured under zinc depletion

  • Emi Nakajima 1,2, Katherine B 1. Hammond, Thomas R. Shearer 2, Mitsuyoshi Azuma 1,2
    1 Senju Pharmaceutical Co., Ltd.
    2 Oregon Health & Science University
  • Eye (Lond). 2014 Jan;28(1):85-92.

Galectin-3 Enhances Epithelial Cell Adhesion and Wound Healing in Rat Cornea

  • C. Yabuta 1, F. Yano 1, A. Fujii 1,2, T.R. Shearer 2, M. Azuma 1,2
    1 Senju Pharmaceutical Co, Ltd
    2 Oregon Health & Science University
  • Ophthalmic Res 2014;51:96–103

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