Publications2006

Retinal penetration of calpain inhibitors in rats after oral administration

  • Yoshihisa Shirasaki1, Masazumi Yamaguchi1, Hiroyuki Miyashita2.
    1 Senju Pharmaceutical Co., Ltd., 2 Kumamoto University
  • J Ocul Pharmacol Ther 22(6) 2006 417-424

Improvement of ocular bioavailability of carteolol by ion pair

  • M. Higashiyama, T. Tajika, K. Inada, A. Ohtori.
  • Journal of Ocular Pharmacology and Therapeutics:22,333-339,2006.

Calpain-specific proteolysis in primate retina: contribution of calpains in cell death.

  • Nakajima E1, David LL2, Brystrom C2, Shearer TR2, Azuma M1,2.
    1 Senju Pharmaceutical Co., Ltd., 2 Oregon Health & Science University
  • Invest Ophthalmol Vis Sci. 2006 46(12): 5469-5475.

Aqueous humor dynamics associated with the phorbol ester-induced decrease in intraocular pressure in the rabbit.

  • Takayuki Oka1, Toru Taniguchi2, Yoshiaki Kitazawa2, Takeshi Sagara3, Teruo Nishida3.
    1 Senju Pharmaceutical Co., Ltd., 2 Gifu University, 3 Yamaguchi University
  • Jpn J Ophthalmol. 2006; 50(6):497-503.

Biochemical propertied of lens-specific calpain Lp85

  • Marjorie Shih, Hong Ma, Emi Nakajima, Larry L. David, Mitsuyoshi Azuma, Thomas R., Shearer
  • Experimental Eye Research 82 (2006) 146-152.

Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension

  • Takayuki Oka, Yoshiyuki Tamada, Emi Nakajima, Thomas R. Shearer, Mitsuyoshi Azuma.
  • Journal of Neuroscience Research. 83(2006)1342-1351.

New Approach in New Drug Development

  • Hideaki Sakaki
  • Japanese Journal of Ocular Pharmacology:20(1),55-58,2006.

Exploration of orally available calpain inhibitors 2.: Peptidyl hemiacetal derivatives

  • Yoshihisa Shirasaki, Masayuki Nakamura, Masazumi Yamaguchi, Hiroyuki Miyashita, Osamu Sakai, and Jun Inoue
  • Journal of Medicinal Chemistry, 2006, 49, 4926-4932.

Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography

  • D. Cuerrier, T. Moldoveanu, J. Inoue, P. L. Davies, and R. L. Campbell
  • Biochemistry 2006, 45, 7446-7452

Exploration of orally available calpain inhibitors Part 3.: Dipeptidyl alpha-ketoamide derivatives containing pyridine moiety

  • Yoshihisa Shirasaki, Hiroyuki Miyashita, Masazumi Yamaguchi
  • Bioorganic & Medicinal Chemistry, 2006, 14, 5691-5698

Low activity by the calpain system in primate lenses causes resistance to calcium-induced proteolysis

  • E. Nakajima1,2, R.D. Walkup1,2, H. Ma2, T.R. Shearer2, M. Azuma1,2
    1 Senju Pharmaceutical Co., Ltd. 2 Oregon Health & Science University
  • Exp Eye Res. 2006 Sep;83(3):593-601.

Involvement of Egr-1 in lens epithelial cell death induced by selenite

  • T.Nakajima1, P.B. Belusko1, R.D. Walkup1, M.Azuma1,2, T.R. Shearer2
    1 Senju Pharmaceutical Co., Ltd. 2 Oregon Health & Science University
  • Exp Eye Res. 2006 May;82(5):874-878.

Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)c

  • Takayuki Oka1, Ryan D. Walkup1, Yoshiyuki Tamada1, Emi Nakajima1, Ayumi Tochigi1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2.
    1 Senju Pharmaceutical Co., Ltd. 2 Oregon Health & Science University
  • Neuroscience. 2006;141(4):2139-2145

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