Publications2005

Non-clinical and Clinical Studies of Gatifloxacin(GATIFLO®0.3% ophthalmic solution)

  • Yoshie Komura and Satoshi Yamamoto
  • Japanese Journal of Ocular Pharmacology Vol. 19 No. 1, 2005 :26-34

Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia

  • Yoshiyuki Tamada, Emi Nakajima, Takeshi Nakajima, Thomas R. Shearer, and Mitsuyoshi Azuma
  • Brain Res. 2005;1050(1-2):148-55.

Exploration of orally available calpain inhibitors: peptidyl a-ketoamides containing an amphiphile at P3 site

  • Yoshihisa Shirasaki, Hiroyuki Miyashita, Masazumi Yamaguchi, Jun Inoue and Masayuki Nakamura
  • Bioorganic & Medicinal Chemistry 13, 4473-4484 (2005)

Calpain-dependent alpha-fodrin cleavage at the sarcolemma in muscle diseases

  • M. Takamure, K.Y. Murata, Y. Tamada, M. Azuma, S. Ueno
  • Muscle Nerve. 2005; 32(3):303-9.

Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate

  • Masazumi Yamaguchi, Shin-ichi Yasueda, Akiharu Isowaki, Makiko Yamamoto, Masako Kimura, Katsuhiro Inada, Akira Ohtori
  • International Journal of Pharmaceutics 301 (2005) 121-128

Stability of latanoprost in an ophthalmic lipid emulsion using polyvinyl alcohol

  • Yusuke Sakai, Shin-Ichi Yasueda and Akira Ohtori
  • International Journal of Pharmaceutics 305 (2005) 176-179

Recent advances in ocular drug delivery system

  • Kakuji Tojo, Tomoko Fujimoto
  • The Pharmaceuticals Monthly 2005. 11 (Vol. 47, No. 12)

Calpain May Contribute to Hereditary Cataract Formation in Sheep

  • Lucinda J. G. Robertson, James D. Morton, Masazumi Yamaguchi, Roy Bickerstaffe, Thomas R. Shearer, Mitsuyoshi Azuma
  • Investigative Ophthalmology and Visual Science (2005); 46; 4634-4640

Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes

  • Emi Nakajima, Takeshi Nakajima, Yoko Minagawa, Thomas R. Shearer, Mitsuyoshi Azuma
  • Journal of Pharmaceutical Sciences 94 (2005) 701-708.

Degradation of human aquaporin 0 by m-calpain

  • Hong Ma, Mitsuyoshi Azuma, Thomas R. Shearer
  • FEBS Letters 579 (2005) 6745-6748.

State of Arts and Perspectives of Therapeutic Agent Development

  • Yamamoto T, Inoue Y, Tsuchiya D, Yamashita H.
  • GANKA OPHTHALMOLOGY 2005 Vol. 47, No. 12 page 1819-1829

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