Comparative studies of HPLC-fluorometry and LC/MS method for the determination of N-acetylneuraminic acid as a marker of deteriorated ophthalmic solutions
- Kinya Iwatsuka1, Shin-ichi Yasueda1, Eiji Bando1, Hiroyuki Fujii1, Takashi Terada1, Hiroya Okubo1, Hiroki Iwamoto2, Mitsuhiro Kinoshita2, Kazuaki Kakehi2
1 Senju Pharmaceutical CO.,LTD., 2 Kinki University - Journal of Chromatography B 879 (2011) , 2866-2870
Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells.
- Takeshi Nakajima1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co., Ltd.
2 Department of Integrative Biosciences, Oregon Health & Science University - Curr Eye Res. 2011 Oct;36(10):930-6
Calpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells.
- Emi Nakajima1,2, Katherine B. Hammond1, Jennifer L. Rosales1, Thomas R. Shearer2 and Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co.,Ltd
2 Department of Integrative Biosciences, Oregon Health & Science University - Invest Ophthalmol Vis Sci. 2011 Sep 1;52(10):7059-67
Effects of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Blood flow in Optic Nerve Head in Rabbits and Axonal Regeneration of Retinal Ganglion Cells in Rats
- Tokushige H1, Waki M1, Takayama Y1, Tanihara H2.
1 Senju Pharmaceutical Co., Ltd, 2 Kumamoto University - Current Eye Research. 2011;36(10):964-970
Clinical Application of Selective ROCK Inhibitor as Drug for Glaucoma
- Hideki Tokushige
- Japanese Journal of Ocular Pharmacology 25:47-50, 2011
Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion.
- Tajika T1, Takahashi H1, Sakai Y1, Fujii H1, Isowaki A2, Sakaki H1.
1 Senju Pharmaceutical Co., Ltd., 2 Senju USA, Inc. - Xenobiotica. 2010 Aug;40(8):569-77.
Ocular distribution of difluprednate ophthalmic emulsion 0.05% in rabbits.
- Tajika T1, Isowaki A2, Sakaki H1.
1 Senju Pharmaceutical Co. Ltd., 2 Senju USA, Inc. - J Ocul Pharmacol Ther. 2011 Feb;27(1):43-9.
Development of an eyedrop container for improvement of instillation adherence
- Tadashi Otsuka
Senju Pharmaceutical CO.,LTD. - Journal of Human Life Engineering 12 (1) , 32-38
Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.
- Tajika T, Waki M, Tsuzuki M, Kida T, Sakaki H.
- J Ocul Pharmacol Ther. 2011 Feb;27(1):29-34.
Calpain Inhibitor Drugs
- M. Azuma 1 and T. R. Shearer 2
1 Senju Pharmaceutical Co., Ltd. 2 Oregon Health Sciences University - Medical Science Digest: Vol.36, No. 3, p.25-31, 2010.
Efficacy and Safety of Prostamide Analog LUMIGAN® Ophthalmic Solution 0.03% for Glaucoma and Ocular Hypertension
- Akemi Mizuno, Tomoyuki Wada, Hideki Tokushige and Mitsuyoshi Isaka
Senju Pharmaceutical Co., Ltd. - Japanese Journal of Ocular Pharmacology 24:19-24, 2010
Effects of Pathological Conditions on Ocular Pharmacokinetics of Antimicrobial Drugs
- Kayoko Ueda 1,2, Akira Ohtori 1 and Kakuji Tojo 2
1 Senju Pharmaceutical Co., Ltd.
2 Kyushu Institute of Technology - Chem. Pharm. Bull. 58 (10) 1301-1305 (2010)
Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.
- A. Morimoto-Tochigi 1, R. D. Walkup 1, E. Nakajima 1, T. R. Shearer 2, M. Azuma 1
1 Senju Pharmaceutical Co., Ltd.
2 Oregon Health & Science University - Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4395-4406.
Patient selection criteria for pilot studies on amelioration of non-neovascular age-related macular degeneration.
- M. Azuma 1, K. Chung 2, A. Fujii 1, T. R. Shearer 2
1 Senju Pharmaceutical Co., Ltd.
2 Oregon Health & Science University - J Ocul Pharmacol Ther. 2010 Aug;26(4):367-371.
Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis
- Tetsuo Kida, Atsuko Fujii, Osamu Sakai, Masahito Iemura, Ikuyo Atsumi, Tomoyuki Wada, Hideyuki Sakaki.
- Experimental Eye Research. 2010;91(1):85-91.
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