2002

XV International Congress of Eye Research (ICER)

• DAY:
• Place：Geneva, Switzerland
• ①DIFFERENTIAL BINDING OF CALPASTATIN TO CALPAIN 2 AND LP82.
  ②INVOLVEMENT OF EGR-1 IN LENS EPITHELIAL CELL DEATH IN SELENITE-INJECTED RATS.
• ①○Emi Nakajima, Chiho Fukiage, Mitsuyoshi Azuma, T.R. Shearer
  ②○Takeshi Nakajima, Yoshiyuki Tamada, Emi Nakajima, Chiho Fukiage, Mitsuyoshi Azuma, T.R. Shearer

XVIIth International Symposium on Medicinal Chemistry

• DAY:
• Place：Barcelona, Spain
• Exploration of Peptidyl Hydrazones as Water-Soluble Calpain Inhibitors
• Masayuki Nakamura and Jun Inoue

Controlled Release Society 29th Annual Meeting

• DAY:
• Place：Seoul, KORIA
• Ocular Bioavailability of Timolol Improved by Sorbic Acid
• M. Higashiyama, K. Inada, A. Ohtori, K. Tojo

2004 FASEB Summer Research Conferences
“Biology of the Calpains in Health and Disease”

• DAY:
• Place：Tucson, AZ
• ①Involvement of calpain in retinopathy
  ②Involvement of calpain in retinal damage induced by elevated intraocular pressure in the rat
• ①Mitsuyoshi Azuma1,2, Yoshiyuki Tamada1, Chiho Fukiage1, Takeshi Nakajima1, Emi Nakajima1,2 and Thomas R. Shearer2
  1 Senju Pharmaceutical Co. Ltd., 2 Oregon Health & Science University
  ②Emi Nakajima1,2, Yoshiyuki Tamada1,Mitsuyoshi Azuma1,2, and Thomas R. Shearer2
  1 Senju Pharmaceutical Co. Ltd., 2 Oregon Health & Science University

Association for Research in Vision and Ophthalmology　(ARVO)　2002 Annual Meeting

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• ①Effect of Polyphenol for Rabbit Corneal Epithelium Storage
  ②Studies on Intraocular Penetration of Ophthalmic Solution by Use of Cyclodextrins for Anti-Cataract Therapeutic Agent
  ③Phosphorylation of Lens-Specific Calpain Lp82: Possible Regulatory Mechamism?
  ④Cleavage of p35, Regulator of CDK5, to p25 by Calpain in Retinal Cell Death
  ⑤Function of Retina-Specific Calpain Rt88 (Splice Variant of p94)
  ⑥Changes in Gene Expression in the Lens Epithelial Cells from Selenite Injected Rats
  ⑦Contribution of Ubiquitous Calpains to Cataractgenesis in Spontaneously Diabetic WBN/Kob Rat
  ⑧Crystallins Proteolyzed by Lens-Specific Calpain Lp82 Are Susceptible to Light Scattering
• ①M.Tsuzuki,　C.Sotozono,　T.Nakamura,　C.Mochida,　Y.Ban,　Y.Sano,　S.Kinoshita
  ②M.Yamaguchi, M.Nakamura, J.Inoue
  ③T.R. Shearer, H. Ma, M. Azuma
  ④E. Nakajima, Y. Tamada, C. Fukiage, M. Azuma, T.R. Shearer
  ⑤C. Fukiage, M. Azuma, T. Nakajima, K. Mizutani, T.R. Shearer
  ⑥T. Nakajima, E. Nakajima, C. Fukiage, M. Azuma, T.R. Shearer
  ⑦M. Azuma, K. Mizutani, C. Fukiage, T.R. Shearer
  ⑧S. Daibo, C. Fukiage, Y. Tamada, N.E. Forsberg, M.K. Duncan, M. Azuma,T.R. Shearer

4th International Symposium on Ocular Pharmacology and Pharmaceutics (4th ISOPP)

• DAY:
• Place：Seville, SPAIN

<< Sponsored Product Session >>
Date: 09:00 - 09:45 a.m. on Friday, March 1st, 2002 at Hall A in Hotel Alfonso XIII
Chairpersons: Hidetoshi Yamashita, M.D.(Prof. of Yamagata Univ. Yamagata, JAPAN)
Atsushi Okumura, Ph.D.(Senior Director of Senju Pharmaceutical, Osaka, JAPAN)

Oral Presentations:
　・SJA6017　　　C. Fukiage
　 Potential for therapeutic use of calpain inhibitor SJA6017 against ocular diseases
　・Y-39983　　　H. Tokushige
　 Therapeutic potential of Rho-associated protein kinase inhibitor (Y-39983) in Glaucoma
　・BRONUCK　　　　M. Wada
　 BRONUCK - the most efficient NSAID: Interim safety and efficacy - post marketing analysis in Japan

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