• DAY:
• Place：Pacifico Yokohama, Yokohama
• ROCK and PKC activation induced by latanoprost acid in cells from human trabecular meshwork
• Mari Furukawa, Hideyuki Sakaki, Mitsuyoshi Azuma
  Senju Pharmaceutical Co., Ltd.

• DAY:
• Place：South Carolina, U.S.A.
• Friday, Oct 28, 2011 10:00 AM - 10:30 AM
  #1 - DETERMINATION OF AUTOANTIBODY-PRODUCING ISOFORMS OF β-H-CRYSTALLINS IN AMERICAN COCKER SPANIELS
• N Kanemaki1 Y Nishina1 H Takahashi1 Y Ichikawa1 C Fukiage2 and M Azuma2
  1 Veterinary Teaching Hospital, Azabu University, Japan
  2 Senju Pharmaceutical Co, LTD.

• DAY:
• Place：Berlin, Germany
• P-15 - SERUM ANTIBODIES AGAINST BETA H-CRYSTALLINS IN AMERICAN COCKER SPANIELS

N Kanemaki1, S Yoda1, Y Nishina1, Y Ichikawa1, C Fukiage2 & M Azuma2
1 Veterinary Teaching Hospital, Azabu University, Japan
2 Senju Pharmaceutical Co., Ltd.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.

Monday, May 2, 2011 8:30 - 10:15 AM 1531/D1100
Could Loss of Calpastatin Lead to Activation of Calpains in Human Lenses?
Takeshi Nakajima1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co., Ltd.
2 Oregon Health & Sciences University

Tuesday, May 3, 2011 8:30 - 10:15 AM 2945/D1039
The Effect Of Calpain Inhibition On Inflammation And Retinal Ganglion Cell Function During The Course Of Experimental Optic Neuritis
Amena W. Smith1, Baerbel Rohrer1, Mitsuyoshi Azuma2, Jun Inoue2, Naren L. Banik1
1 Medical University of South Carolina, Charleston, SC
2 Senju Pharmaceutical Co., Ltd.

Tuesday, May 3, 2011 1:45 - 3:30 PM 3217/A465
Transcorneal Delivery of FK962 is Altered by Flap Surgery in Rabbits
Ayumi Yoshimatsu, Chiho Yabuta, Akira Ohtori, Mitsuyoshi Azuma
Senju Pharmaceutical Co., Ltd.

Tuesday, May 3, 2011 3:45 - 5:30 PM 3714/D847
Lacritin, But Not Carbachol, Induces Secretion Of Tear Proteins From Cytokine-treated Monkey Acinar Cells
Atsuko Fujii1, Ryan D. Walkup1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd., Beaverton, OR
2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

Tuesday, May 3, 2011 1:45 - 3:30 PM 3233/A481
Ocular Pharmacokinetics For Aphakic Eyes
Kayoko Ueda1,2, Akira Ohtori1,3, Kakuji Tojo2,3
1 Senju Pharmaceutical Co., Ltd.
2 Graduate school of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
3 Laboratory of Ocular Drug Delivery System, Iizuka Campus, Kyushu Institute of Technology, Fukuoka, Japan

Tuesday, May 3, 2011 1:45 - 3:30 PM 3242/A490
Drug Penetration to the Posterior Vitreous Body after Topical Instillation
Yuko Shikamura1,2, Akira Ohtori1,3, Kakuji Tojo2,3
1 Senju Senju Pharmaceutical Co., Ltd.
2 Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
3 Laboratory of Ocular Drug Delivery System, Kyushu Institute of Technology, Fukuoka, Japan

Thursday, May 5, 2011 11:15 AM - 1:00 PM 6425/D889
Involvement of NFκB on Cytokine Production From Mast Cells and Conjunctival Fibroblasts Cultured Under Allergic Conditions
Osamu Sakai, Yoshiyuki Tamada, Mitsuyoshi Azuma
Senju Pharmaceutical Co., Ltd.

Thursday, May 5, 2011 1:15 - 1:30 PM 6594
ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells
Naoki Okumura1, Noriko Koizumi2, Kenta Yamasaki2, Morio Ueno1, Yuji Sakamoto2, Yoshihiro Sowa1, Toshiyuki Sakai1, Junji Hamuro1, Shigeru Kinoshita1
1 Kyoto Prefectural University Med, Kyoto, Japan
2 Biomedical Engineering, Doshisha University, Kyotanabe, Japan

Thursday, May 5, 2011 2:15 - 2:30 PM 6598
Cell-Injection Therapy using Cultivated Corneal Endothelial Cells Combined with a ROCK Inhibitor in a Primate Model
Noriko Koizumi1, Naoki Okumura2, Kenta Yamasaki1, Morio Ueno2, Yuji Sakamoto1, Hiroaki Takahashi1, Ryuzo Torii3, Junji Hamuro2, Shigeru Kinoshita2
1 Biomedical Engineering, Doshisha University, Kyotanabe City, Japan
2 Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan
3 Research Center for Animal Life Science, Shiga University of Medical Science, Otsu City, Japan

Thursday, May 5, 2011 11:15 AM - 1:00 PM 6465/D929
ROCK Inhibition Regulates the Cell Adhesion of Corneal Endothelial Cellsz
Kyoko Kumagai1, Noriko Koizumi2, Naoki Okumura3, Kenta Yamazaki2, Morio Ueno3, Yuji Sakamoto2, Nagahisa Yoshimura1, Junji Hamuro3, Shigeru Kinoshita3
1 Ophthalmology, Kyoto university, Kyoto, Japan
2 Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan
3 Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

• DAY:
• Place：Montreal, QC, Canada
• CALPAIN, NOT CASPASE, IS THE CAUSATIVE PROTEASE FOR HYPOXIC DAMAGE IN CULTURED MONKEY RETINAL CELLS
• E. Nakajima 1,2, K. B. Hammond 1,2, T.R. Shearer 2, M.Azuma 1,2.
  1 Senju Pharmaceutical Co., Ltd.
  2 Oregon Health & Science University

Presentation date: July 20, 2010

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Sunday, May 2, 2010 8:30 - 10:15 AM
  371/D858 –
  Effect of Recombinant Galectin-3 on Corneal Wound Healing
  F. Yano, C. Yabuta, M. Azuma. Senju Pharmaceutical, Kobe, Japan.
  
  Sunday, May 2, 2010 11:15 AM - 1:00 PM
  539/A220 –
  Patient Selection Criteria for Drug Efficacy Studies on Dry AMD
  A. Fujii1, K. Chung2A, M. Azuma1,2B, T.R. Shearer2B.
  1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR; A Department of Ophthalmology, B Department of Integrative Biosciences, 2 Oregon Health & Science University, Portland, OR.
  
  Sunday, May 2, 2010 11:15 AM - 1:00 PM
  821/D1033 –
  Calpain Inhibition Confers Histological and Functional Neuroprotection to Retinal Ganglion Cells in Experimental Optic Neuritis
  A.W. Smith1, J.T. Butler1, B. Rohrer2, M. Azuma3, J. Inoue4, N.L. Banik5.
  1 Neuroscience, Medical University of South Carolina, Charleston, SC; 2 Ophthalmology, Med Univ of South Carolina, Charleston, SC; 3 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Kobe, Japan; 4 Senju USA Inc, Woodland Hills, CA; 5 Neurology, Medical Univ of South Carolina, Charleston, SC.
  
  Tuesday, May 4, 2010 8:30 - 10:15 AM
  2610/A417 –
  Involvement of Calpain in Ionomycin-Induced Cell Death in Cultured Mouse Lens Epithelial Cells
  T. Nakajima1, T.R. Shearer2, M. Azuma2,3.
  1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR; 3 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR.
  
  Tuesday, May 4, 2010 1:45 - 3:30 PM
  3406/D992 –
  FK962 Enhances Axonal Regeneration in Cultured Rat Trigeminal Ganglion Cells
  Y. Kishimoto, C. Yabuta, M. Azuma.
  Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan.
  
  Tuesday, May 4, 2010 1:45 - 3:30 PM
  3407/D993 –
  Topical Application of FK962 Enhances Axonal Elongation and Corneal Sensitivity in a Rabbit Model of LASIK Surgery
  T. Oka, F. Yano, Y. Tamada, C. Yabuta, M. Azuma. Senju Pharmaceutical Co., Ltd., Kobe, Japan.
  
  Wednesday, May 5, 2010 8:30 - 10:15 AM
  4178/D729 –
  Functions of Primate Lacritin: Enhanced Secretion of Tear Proteins From Lacrimal Acinar Cells and Promotion of Corneal Epithelial Cell Adhesion
  A. Morimoto-Tochigi1, T. Nakajima1, A. Fujii2, T.R. Shearer3, M. Azuma2,3.
  1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR; 3 Department of Integrative Biosciences, Oregon Health & Sciences University, Portland, OR.
  
  Thursday, May 6, 2010 8:30 - 10:15 AM
  5303/A231 –
  A Hydrogel Ring as a New Transscleral Drug Delivery System to the Posterior Eye
  Y. Shikamura1,2, A. Ohtori1, T. Matsunaga3, Y. Yamazaki3, T. Sato3, K. Tojo2.
  1 Research Laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan; 3 Research Laboratories, Seed Co., Ltd., Saitama, Japan.

• DAY:
• Place：Anaheim, CA, U.S.A.
• PACAP induces axonal elongation in cultured monkey trigeminal ganglion cells
  (Presentation:2010.04.26)
• ○E. Nakajima1,2, Ryan D. Walkup1,2, Thomas　R. Shearer2, M. Azuma1,2.
  1 Senju Pharmaceutical Co,.Ltd., 2 Oregon Health & Science University

• DAY:
• Place：Suita Campus, Osaka University
• Contribution of experimental animal technologist to Refinement and Reduction
• Yuji Sakamoto
  Senju Pharmaceutical Co,.Ltd., The Japanese Association for Experimental Animal Technologists

• DAY:
• Place：Hong Kong Convention and Exhibition Centre, Hong Kong, China
• ①Effect of Topical Bromfenac Sodium 0.1% Ophthalmic Solution on Laser-Induced Choroidal Neovascularization in Mice
  ②Effect of Bromfenac Sodium on Acute and Chronic Uveitis in Rabbits
• ①T. Kida1, T. Ogawa2, H. Sakaki1, J. Han3, C. K. Song3, T. R. McNamara3.
  1 Senju Pharmaceutical Co Ltd, 2 Senju USA, Inc. 3 ISTA Pharmaceuticals, Inc., Irvine, CA.
  ②T. Ogawa1, T. Kida2.
  1 Senju USA, Inc, 2 Senju Pharmaceutical Co., Ltd.

• DAY:
• Place：Alumni Hall, 4227 Fifth Avenue, Pittsburgh, Pennsylvania, 15260
• Design of calpain inhibitors to enhance the penetration to the retina
• Y.Shirasaki, H.Takahashi, M.Yamaguchi, J.Inoue.
  Senju Pharmaceutical Co., Ltd.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Corneal Endothelial Cell Proliferation is Enhanced by a Single Injection of Connexin 43 siRNA in a Primate Endothelial Injury Model

N.Koizumi1,2, Y.Nakano2,3, Y.Sakamoto4, N.Okumura2, P.Dai3, H.Tsuchiya5, R.Torii5, S.Kinoshita2, T.Takamatsu3.
1 Research Center for Regenerative Medicine, Doshisha University; Kyoto, Japan, 2Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 3Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 4Research Laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan, 5Research Center for Animal Life Science, Shiga University of Medical Science; Otsu, Japan.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Effects of Bromfenac Sodium on Acute and Chronic Uveitis in Rabbits
• T. Ogawa1, T. Kida2, J. Han3, C.K. Song3, T.R. McNamara3.
  1 Senju USA, Inc., Woodland Hills, CA; 2Research laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 3ISTA Pharmaceuticals, Inc., Irvine, CA.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Secretion of Lacritin from Cultured Monkey Lacrimal Acinar Cells
• A. Tochigi1, R.D. Walkup1, T. Nakajima1, T.R. Shearer2, M. Azuma1,2.
  1 Senju Pharmaceutical Co., Ltd., 3 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Involvement of NFkB and STAT6 on Eotaxin-1, IL-8 and RANTES production in human conjunctival fibroblasts and epithelial cells
• O.Sakai, H.Takahashi, Y.Tamada, J.Inoue, M.Azuma.
  Research Laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

• DAY:
• Place：Fort Lauderdale, Florida, U.S.A.
• Induction of Tube Formation by Angiogenic Factors Secreted From Cultured RPE Cells During Hypoxia
• T. Nakajima1, E. Nakajima1, T.R. Shearer2, M. Azuma1,2.
  1 Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR.