Meetings of the Minds

The Association for Research in Vision and Ophthalmology (ARVO) 2015 Annual Meeting

  • DAY: to be released
  • Place:Denver, Colorado
  • 〔263/C0135〕
    Intracellular uptake of drugs into cultured human corneal epithelial cells
    A. Mori, C. Yabuta, A. Ohtori, M Azuma

    〔2309/B0214〕
    Transcriptome analysis of VEGF-induced human retinal microvascular endothelial cells
    M. Noda, T. Nakajima, M. Azuma

    〔3650/A0144〕
    Protective Role of Glutathione Peroxidase 4 in Retinal Ganglion Cells
    T. Uchida1,2, O. Sakai1,2, T. Ueta1, S. Amano3,4
    1 Department of Ophthalmology, University of Tokyo School of Medicine
    2 Senju Pharmaceutical Co. Ltd.
    3 Inouye Eye Hospital
    4 Miyata Eye Hospital

    〔3777/C0019〕
    Monkey RPE cell death induced by oligomeric Aβ
    M. Hirata1, T.R. Shearer2 and M. Azuma1, 2
    1 Senju Pharmaceutical Co. Ltd.
    2 Department of Integrative Biosciences, Oregon Health & Science University

    〔5481/B0040〕
    miRNA-203 regulates proliferation in cultured human corneal epithelial cells
    A. Nakagawa, T. Nakajima, M. Azuma

The Association for Research in Vision and Ophthalmology (ARVO) 2014 Annual Meeting

  • DAY: to be released
  • Place:Orlando, Florida
  • Monday, May 5, 2014, 11:00 AM - 12:45 PM
    2031 - C0050
    Role of glutathione peroxidase 4 in corneal endothelial cells
    O. Sakai 1), 2), T. Ueda 1), S. Amano 1)
    1) Department of Ophthalmology, Tokyo University
    2) Senju Pharmaceutical Co. Ltd.

    Sunday, May 4, 2014, 3:15 PM - 5:00 PM
    996 - A0385
    Selecting Fuchs Patients for Drug Trials Involving Endothelial Cell Migration
    A. Fujii 1),3), W. Chamberlain 2), M. Azuma 1),3), T.R. Shearer3)
    1) Senju Pharmaceutical Co. Ltd.
    2) Department of Ophthalmology, Oregon Health & Science University, Portland, OR
    3) Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

    Monday,May 5, 2014, 11:00 AM - 12:45 PM
    1744 - A0113
    Hypoxia activates calpain in the nerve fiber layer of monkey retinal explants
    M. Hirata 1),2), E. Nakajima 1), T.R. Shearer2), M. Azuma 1),2)
    1) Senju Pharmaceutical Co. Ltd.
    2) Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

    Monday, May 5, 2014, 11:00 AM - 12:45 PM
    1724 - A0093
    FK962 enhances neurite elongation in cultured rat retinal ganglion cells
    M. Kakehi 1), T. Yabuta 1), A. Yoshimatsu 1), Y. Kishimoto 1), T.R. Shearer2), M. Azuma 1),2)
    1) Senju Pharmaceutical Co. Ltd.
    2) Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

The Society of Toxicology (SOT) 2014 annual meeting

  • DAY: to be released
  • Place:Phoenix, Arizona, USA
  • Abstract#/Poster#:1640/333
    Ocular anatomical features in rabbits, dogs and monkeys; a comparison with human
  • Ikuyo Atsumi, Masaaki Kurata, Hideyuki Sakaki

The 39th Annual Meeting of the Japanese Society of Toxicology (39JSOT)

  • DAY: to be released
  • Place:Sendai International Center, Sendai
  • Investigation of comet assay using Human Corneal Epithelial Cell (HCE-T)
        (Oral: July 18, Poster: July 19)
  • ○Masaki KAKEHI, Fumiko MIYASHITA, Mari FURUKAWA, Yoshinori YAMAGIWA, Yu HARANOSONO, Ikuyo ATSUMI, Shingo NEMOTO, Masaaki KURATA, Hideyuki SAKAKI

The Japanese Association of Pharmaceutical Medicine (JAPhMed) 2012 3rd Annual Meeting

  • DAY: to be released
  • Place:Translational Research Informatics Center, Kobe
  • Approach of non-clinical drug safety evaluation on ocular toxicity for reducing human risk
  • Ikuyo Atsumi

The Association for Research in Vision and Ophthalmology (ARVO) 2012 Annual Meeting (Ⅱ)

  • DAY: to be released
  • Place:Fort Lauderdale, Florida, U.S.A

Program#/Poster#: 4279/A469
Abstract Title: Calpain Protease Causes Hypoxia-Induced Proteolysis in Cultured Human Retina
Presentation Start/End Time: Wednesday, May 09, 2012, 8:30 AM -10:15 AM
Mitsuyoshi Azuma1,2, Katherine B. Hammond1,2, Emi Nakajima1,2, Thomas R. Shearer2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd., Beaverton, OR
2 Integrative Biosciences, Oregon Health & Science University, Portland, OR

Program#/Poster#: 4280/A470
Abstract Title: Contribution of Calpain and Caspases to Cell Death from Zinc Depletion in Cultured Monkey RPE
Presentation Start/End Time: Wednesday, May 09, 2012, 8:30 AM -10:15 AM
Katherine B. Hammond1,2, Emi Nakajima1,2, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co. Ltd., Beaverton, OR
2 Integrative Biosciences, Oregon Health & Science University, Portland, OR

Program#/Poster#: 5372/A397
Abstract Title: Involvement Of Calpain In The Degeneration And Dysfunction Of Rat Retinal Nerve Fiber Layers Due To Acute Ocular Hypertension
Presentation Start/End Time: Wednesday, May 09, 2012, 3:45 PM - 5:30 PM
Rie Suzuki1, Takayuki Oka1, Yoshiyuki Tamada1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co Ltd, Kobe, Japan
2 Integrative Biosciences-Dentistry, Oregon Health Sciences University, Portland, OR

Program#/Poster# 1738
Abstract Title: Cell-injection Therapy using Cultivated Human Corneal Endothelial Cells in a Primate Model
Presentation Start/End Time: Monday, May 07, 2012, 2:30 PM - 2:45 PM
Noriko Koizumi1,2, Naoki Okumura1,2, Yuji Sakamoto1,4, Kenta Yamasaki1, Makiko Nakahara1, Ryuzo Torii3, Morio Ueno2, Junji Hamuro2, Shigeru Kinoshita2
1 Biomedical Engineering, Doshisha University, Kyotanabe, Japan
2 Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan
3 Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Japan
4 Senju Pharmaceutical Co Ltd, Kobe, Japan

Program#/Poster#: 5999/D820
Abstract Title: Rock Inhibitor Eye Drops Accelerate Corneal Endothelium Wound Healing In A Primate Model
Presentation Start/End Time: Thursday, May 10, 2012, 8:30 AM -10:15 AM
Naoki Okumura1,2, Noriko Koizumi1,2, Morio Ueno2, Yuji Sakamoto1,4, Hiroaki Takahashi1, Kenta Yamasaki1, Ryuzo Torii3, Junji Hamuro2, Shigeru Kinoshita2
1 Biomedical Engineering, Doshisha University, Kyotanabe, Japan
2 Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan
3 Research Center for Animal Life Science, Shiga University, Otsu, Japan
4 Senju Pharmaceutical Co Ltd, Kobe, Japan

The Association for Research in Vision and Ophthalmology (ARVO) 2012 Annual Meeting (Ⅰ)

  • DAY: to be released
  • Place:Fort Lauderdale, Florida, U.S.A

Program#/Poster#: 1140/A605
Abstract Title: Contribution of Calpain and Caspases to Cell Death in Monkey RPE Cells Cultured Under Hypoxia or with A2E
Presentation Start/End Time: Sunday, May 06, 2012, 3:15 PM - 5:00 PM
Ryan D. Walkup1,2, Katherine B. Hammond1,2, Emi Nakajima1,2, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co. Ltd., Beaverton, OR
2 Integrative Biosciences, Oregon Health & Science University, Portland, OR

Program#/Poster#: 1799/A262
Abstract Title: Role of GDNF in FK962-induced Neurite Elongation of Cultured Rat Trigeminal Ganglion Cells
Presentation Start/End Time: Monday, May 07, 2012, 1:45 PM - 3:30 PM
Mamiko Noda1, Yayoi Kishimoto1, Chiho Yabuta1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co.,Ltd., Kobe, Japan
2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

Program#/Poster#: 2359/A376
Abstract Title: Galection-3 Facilitates Corneal Epithelial Wound Healing In A Rat Model Of Dry Eye
Presentation Start/End Time: Monday, May 07, 2012, 3:45 PM - 5:30 PM
Ayano Sasaki1, Yoshiyuki Tamada1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co Ltd, Kobe, Japan
2 Integrative Biosciences-Dentistry, Oregon Health Sciences University, Portland, OR

Program#/Poster#: 3010/D859
Abstract Title: Increased Expression of Integrin α Chains and Their Ligands during Laser-Induced Neovascularization of Rat Choroid
Presentation Start/End Time: Tuesday, May 08, 2012, 8:30 AM -10:15 AM
Takeshi Nakajima1, Thomas R. Shearer2, Mitsuyoshi Azuma3,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Kobe, Japan
2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR
3 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Beaverton, OR

Program#/Poster#: 3489/D793
Abstract Title: Involvement of Calpain in Retinal Ganglion Cell Death in a Rat Model of Anterior Ischemic Optic Neuropathy
Presentation Start/End Time: Tuesday, May 08, 2012, 1:45 PM - 3:30 PM
Takayuki Oka1, Rie Suzuki1, Yoshiyuki Tamada1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co Ltd, Kobe, Japan
2 Integrative Biosciences-Dentistry, Oregon Health Sciences University, Portland, OR

Program#/Poster#: 3540/D918
Abstract Title: Galectin-3 Facilitates Epithelial Wound Healing in Explanted Monkey Corneas
Presentation Start/End Time: Tuesday, May 08, 2012, 1:45 PM - 3:30 PM
Atsuko Fujii1,2, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd., Beaverton, OR
2 Integrative Biosciences, Oregon Health & Science University, Portland, OR

The 132nd Annual Meating of the pharmaceutical Society of Japan

  • DAY: to be released
  • Place:Hokkaido University, Sapporo
  • No. 31P2-pm113 (3/31)
    Effectivity of bromfenac for antimicrobial activity in bromfenac ophthalmic solution.
  • ○Wakiko Asayama, Shuuichi Nishihata, Suzuka Iemoto, Masazumi Yamaguchi, Shinichi Yasueda
    Senju Pharmaceutical CO.,LTD.

The 132nd Annual Meating of the pharmaceutical Society of Japan

  • DAY: to be released
  • Place:Hokkaido University, Sapporo
  • No. 29P2-pm051 (3/29)
    Comparative studies of HPLC-fluorometry and LC/MS method for the determination of N-acetylneuraminic acid as a marker of deteriorated ophthalmic solutions.
  • ○Kinya Iwatsuka1, Shin-ichi Yasueda1, Eiji Bando1, Hiroyuki Fujii1, Takashi Terada1, Hiroya Okubo1, Hiroki Iwamoto2, Mitsuhiro Kinoshita2, Kazuaki Kakehi2
    1 Senju Pharmaceutical CO.,LTD.
    2 Faculty of Pharmaceutical Sciences, Kinki University

The 34th Annual Meeting of the Molecular Biology Society of Japan

  • DAY: to be released
  • Place:Pacifico Yokohama, Yokohama
  • ROCK and PKC activation induced by latanoprost acid in cells from human trabecular meshwork
  • Mari Furukawa, Hideyuki Sakaki, Mitsuyoshi Azuma
    Senju Pharmaceutical Co., Ltd.

American College of Veterinary Opthamologists (ACVO) 2011 Conference

  • DAY: to be released
  • Place:South Carolina, U.S.A.
  • Friday, Oct 28, 2011 10:00 AM - 10:30 AM
    #1 - DETERMINATION OF AUTOANTIBODY-PRODUCING ISOFORMS OF β-H-CRYSTALLINS IN AMERICAN COCKER SPANIELS
  • N Kanemaki1 Y Nishina1 H Takahashi1 Y Ichikawa1 C Fukiage2 and M Azuma2
    1 Veterinary Teaching Hospital, Azabu University, Japan
    2 Senju Pharmaceutical Co, LTD.

European College of Veterinary Ophthalmologists (ECVO) Congress 2011

  • DAY: to be released
  • Place:Berlin, Germany
  • P-15 - SERUM ANTIBODIES AGAINST BETA H-CRYSTALLINS IN AMERICAN COCKER SPANIELS

N Kanemaki1, S Yoda1, Y Nishina1, Y Ichikawa1, C Fukiage2 & M Azuma2
1 Veterinary Teaching Hospital, Azabu University, Japan
2 Senju Pharmaceutical Co., Ltd.

The Association for Research in Vision and Ophthalmology (ARVO) 2011 Annual Meeting

  • DAY: to be released
  • Place:Fort Lauderdale, Florida, U.S.A.

Monday, May 2, 2011 8:30 - 10:15 AM 1531/D1100
Could Loss of Calpastatin Lead to Activation of Calpains in Human Lenses?
Takeshi Nakajima1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Pharmaceutical Co., Ltd.
2 Oregon Health & Sciences University

Tuesday, May 3, 2011 8:30 - 10:15 AM 2945/D1039
The Effect Of Calpain Inhibition On Inflammation And Retinal Ganglion Cell Function During The Course Of Experimental Optic Neuritis
Amena W. Smith1, Baerbel Rohrer1, Mitsuyoshi Azuma2, Jun Inoue2, Naren L. Banik1
1 Medical University of South Carolina, Charleston, SC
2 Senju Pharmaceutical Co., Ltd.

Tuesday, May 3, 2011 1:45 - 3:30 PM 3217/A465
Transcorneal Delivery of FK962 is Altered by Flap Surgery in Rabbits
Ayumi Yoshimatsu, Chiho Yabuta, Akira Ohtori, Mitsuyoshi Azuma
Senju Pharmaceutical Co., Ltd.

Tuesday, May 3, 2011 3:45 - 5:30 PM 3714/D847
Lacritin, But Not Carbachol, Induces Secretion Of Tear Proteins From Cytokine-treated Monkey Acinar Cells
Atsuko Fujii1, Ryan D. Walkup1, Thomas R. Shearer2, Mitsuyoshi Azuma1,2
1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd., Beaverton, OR
2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR

Tuesday, May 3, 2011 1:45 - 3:30 PM 3233/A481
Ocular Pharmacokinetics For Aphakic Eyes
Kayoko Ueda1,2, Akira Ohtori1,3, Kakuji Tojo2,3
1 Senju Pharmaceutical Co., Ltd.
2 Graduate school of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
3 Laboratory of Ocular Drug Delivery System, Iizuka Campus, Kyushu Institute of Technology, Fukuoka, Japan

Tuesday, May 3, 2011 1:45 - 3:30 PM 3242/A490
Drug Penetration to the Posterior Vitreous Body after Topical Instillation
Yuko Shikamura1,2, Akira Ohtori1,3, Kakuji Tojo2,3
1 Senju Senju Pharmaceutical Co., Ltd.
2 Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
3 Laboratory of Ocular Drug Delivery System, Kyushu Institute of Technology, Fukuoka, Japan

Thursday, May 5, 2011 11:15 AM - 1:00 PM 6425/D889
Involvement of NFκB on Cytokine Production From Mast Cells and Conjunctival Fibroblasts Cultured Under Allergic Conditions
Osamu Sakai, Yoshiyuki Tamada, Mitsuyoshi Azuma
Senju Pharmaceutical Co., Ltd.

Thursday, May 5, 2011 1:15 - 1:30 PM 6594
ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells
Naoki Okumura1, Noriko Koizumi2, Kenta Yamasaki2, Morio Ueno1, Yuji Sakamoto2, Yoshihiro Sowa1, Toshiyuki Sakai1, Junji Hamuro1, Shigeru Kinoshita1
1 Kyoto Prefectural University Med, Kyoto, Japan
2 Biomedical Engineering, Doshisha University, Kyotanabe, Japan

Thursday, May 5, 2011 2:15 - 2:30 PM 6598
Cell-Injection Therapy using Cultivated Corneal Endothelial Cells Combined with a ROCK Inhibitor in a Primate Model
Noriko Koizumi1, Naoki Okumura2, Kenta Yamasaki1, Morio Ueno2, Yuji Sakamoto1, Hiroaki Takahashi1, Ryuzo Torii3, Junji Hamuro2, Shigeru Kinoshita2
1 Biomedical Engineering, Doshisha University, Kyotanabe City, Japan
2 Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan
3 Research Center for Animal Life Science, Shiga University of Medical Science, Otsu City, Japan

Thursday, May 5, 2011 11:15 AM - 1:00 PM 6465/D929
ROCK Inhibition Regulates the Cell Adhesion of Corneal Endothelial Cellsz
Kyoko Kumagai1, Noriko Koizumi2, Naoki Okumura3, Kenta Yamazaki2, Morio Ueno3, Yuji Sakamoto2, Nagahisa Yoshimura1, Junji Hamuro3, Shigeru Kinoshita3
1 Ophthalmology, Kyoto university, Kyoto, Japan
2 Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan
3 Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

XIX Biennial Meeting of the International Society for Eye Research (ISER 2010)

  • DAY: to be released
  • Place:Montreal, QC, Canada
  • CALPAIN, NOT CASPASE, IS THE CAUSATIVE PROTEASE FOR HYPOXIC DAMAGE IN CULTURED MONKEY RETINAL CELLS
  • E. Nakajima 1,2, K. B. Hammond 1,2, T.R. Shearer 2, M.Azuma 1,2.
    1 Senju Pharmaceutical Co., Ltd.
    2 Oregon Health & Science University

Presentation date: July 20, 2010

The Association for Research in Vision and Ophthalmology (ARVO) 2010 Annual Meeting

  • DAY: to be released
  • Place:Fort Lauderdale, Florida, U.S.A.
  • Sunday, May 2, 2010 8:30 - 10:15 AM
    371/D858 –
    Effect of Recombinant Galectin-3 on Corneal Wound Healing
    F. Yano, C. Yabuta, M. Azuma. Senju Pharmaceutical, Kobe, Japan.

    Sunday, May 2, 2010 11:15 AM - 1:00 PM
    539/A220 –
    Patient Selection Criteria for Drug Efficacy Studies on Dry AMD
    A. Fujii1, K. Chung2A, M. Azuma1,2B, T.R. Shearer2B.
    1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR; A Department of Ophthalmology, B Department of Integrative Biosciences, 2 Oregon Health & Science University, Portland, OR.

    Sunday, May 2, 2010 11:15 AM - 1:00 PM
    821/D1033 –
    Calpain Inhibition Confers Histological and Functional Neuroprotection to Retinal Ganglion Cells in Experimental Optic Neuritis
    A.W. Smith1, J.T. Butler1, B. Rohrer2, M. Azuma3, J. Inoue4, N.L. Banik5.
    1 Neuroscience, Medical University of South Carolina, Charleston, SC; 2 Ophthalmology, Med Univ of South Carolina, Charleston, SC; 3 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Kobe, Japan; 4 Senju USA Inc, Woodland Hills, CA; 5 Neurology, Medical Univ of South Carolina, Charleston, SC.

    Tuesday, May 4, 2010 8:30 - 10:15 AM
    2610/A417 –
    Involvement of Calpain in Ionomycin-Induced Cell Death in Cultured Mouse Lens Epithelial Cells
    T. Nakajima1, T.R. Shearer2, M. Azuma2,3.
    1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR; 3 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR.

    Tuesday, May 4, 2010 1:45 - 3:30 PM
    3406/D992 –
    FK962 Enhances Axonal Regeneration in Cultured Rat Trigeminal Ganglion Cells
    Y. Kishimoto, C. Yabuta, M. Azuma.
    Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan.

    Tuesday, May 4, 2010 1:45 - 3:30 PM
    3407/D993 –
    Topical Application of FK962 Enhances Axonal Elongation and Corneal Sensitivity in a Rabbit Model of LASIK Surgery
    T. Oka, F. Yano, Y. Tamada, C. Yabuta, M. Azuma. Senju Pharmaceutical Co., Ltd., Kobe, Japan.

    Wednesday, May 5, 2010 8:30 - 10:15 AM
    4178/D729 –
    Functions of Primate Lacritin: Enhanced Secretion of Tear Proteins From Lacrimal Acinar Cells and Promotion of Corneal Epithelial Cell Adhesion
    A. Morimoto-Tochigi1, T. Nakajima1, A. Fujii2, T.R. Shearer3, M. Azuma2,3.
    1 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co., Ltd., Beaverton, OR; 3 Department of Integrative Biosciences, Oregon Health & Sciences University, Portland, OR.

    Thursday, May 6, 2010 8:30 - 10:15 AM
    5303/A231 –
    A Hydrogel Ring as a New Transscleral Drug Delivery System to the Posterior Eye
    Y. Shikamura1,2, A. Ohtori1, T. Matsunaga3, Y. Yamazaki3, T. Sato3, K. Tojo2.
    1 Research Laboratories, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2 Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan; 3 Research Laboratories, Seed Co., Ltd., Saitama, Japan.

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